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Recent Advances in Small Peptides of Marine Origin in Cancer Therapy

期刊

MARINE DRUGS
卷 19, 期 2, 页码 -

出版社

MDPI
DOI: 10.3390/md19020115

关键词

marine organism; anticancer medicine; small peptide; liner peptide; cyclic peptide

资金

  1. National Natural Science Foundation of China [91856126]
  2. Natural Science Foundation of Ningbo City [2018A610410]
  3. Foundation of Ningbo University [XYL20023]
  4. National 111 Project of China [D16013]
  5. Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund
  6. K.C. Wong Magna Fund in Ningbo University

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Small peptides derived from marine organisms show promise in anticancer research due to their fast absorption and low gastrointestinal burden, offering potential advantages over traditional therapies. Further research is needed to fully understand their mechanisms and potential clinical applications.
Cancer is one of the leading causes of death in the world, and antineoplastic drug research continues to be a major field in medicine development. The marine milieu has thousands of biological species that are a valuable source of novel functional proteins and peptides, which have been used in the treatment of many diseases, including cancer. In contrast with proteins and polypeptides, small peptides (with a molecular weight of less than 1000 Da) have overwhelming advantages, such as preferential and fast absorption, which can decrease the burden on human gastrointestinal function. Besides, these peptides are only connected by a few peptide bonds, and their small molecular weight makes it easy to modify and synthesize them. Specifically, small peptides can deliver nutrients and drugs to cells and tissues in the body. These characteristics make them stand out in relation to targeted drug therapy. Nowadays, the anticancer mechanisms of the small marine peptides are still largely not well understood; however, several marine peptides have been applied in preclinical treatment. This paper highlights the anticancer linear and cyclic small peptides in marine resources and presents a review of peptides and the derivatives and their mechanisms.

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