4.7 Article

A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge

期刊

MARINE DRUGS
卷 19, 期 2, 页码 -

出版社

MDPI
DOI: 10.3390/md19020105

关键词

antibiotic; deep sea; sea sponge; bioprospecting; natural product; secondary metabolites; biosynthetic gene clusters; genome mining; nanopore sequencing

资金

  1. Biotechnology and Biological Sciences Research Council [BB/L01386X/1, BB/T001968/1, BB/M025624/1]
  2. Engineering and Physical Sciences Research Council [EP/L016494/1]
  3. Defence Science and Technology Laboratory
  4. GW4BioMedDTP PhD studentship
  5. Medical Research Council [MR/N0137941/1]
  6. European Research Council (ERC Consolidator Grant) [278705]
  7. BBSRC [BB/M025624/1, BB/T001968/1, BB/L01386X/1] Funding Source: UKRI
  8. MRC [1952965] Funding Source: UKRI

向作者/读者索取更多资源

To combat antibiotic resistance, new bioactive compounds are needed, and the microbiome of sea sponges, especially from the deep sea, shows potential as a source for novel natural products. The isolation of a Micromonospora strain from a deep-sea sponge has shown production of antibiotics and antitumor compounds effective against multidrug-resistant clinical isolates, demonstrating the value of targeting deep-sea sponge microbiomes for drug discovery.
To tackle the growing problem of antibiotic resistance, it is essential to identify new bioactive compounds that are effective against resistant microbes and safe to use. Natural products and their derivatives are, and will continue to be, an important source of these molecules. Sea sponges harbour a diverse microbiome that co-exists with the sponge, and these bacterial communities produce a rich array of bioactive metabolites for protection and resource competition. For these reasons, the sponge microbiota constitutes a potential source of clinically relevant natural products. To date, efforts in bioprospecting for these compounds have focused predominantly on sponge specimens isolated from shallow water, with much still to be learned about samples from the deep sea. Here we report the isolation of a new Micromonospora strain, designated 28ISP2-46(T), recovered from the microbiome of a mid-Atlantic deep-sea sponge. Whole-genome sequencing reveals the capacity of this bacterium to produce a diverse array of natural products, including kosinostatin and isoquinocycline B, which exhibit both antibiotic and antitumour properties. Both compounds were isolated from 28ISP2-46(T) fermentation broths and were found to be effective against a plethora of multidrug-resistant clinical isolates. This study suggests that the marine production of isoquinocyclines may be more widespread than previously supposed and demonstrates the value of targeting the deep-sea sponge microbiome as a source of novel microbial life with exploitable biosynthetic potential.

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