期刊
MAMMALIAN GENOME
卷 32, 期 4, 页码 239-250出版社
SPRINGER
DOI: 10.1007/s00335-021-09863-7
关键词
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资金
- NIH Office of the Director [U42 OD010918-21]
This article highlights the impact of gut microbiota on research outcomes, showing that manipulating the GM in laboratory mice can enhance the predictive power of data. Various experimental factors affect the composition of the GM in mice, suggesting measures to improve experimental reproducibility and translatability.
Just as the gut microbiota (GM) is now recognized as an integral mediator of environmental influences on human physiology, susceptibility to disease, and response to pharmacological intervention, so too does the GM of laboratory mice affect the phenotype of research using mouse models. Multiple experimental factors have been shown to affect the composition of the GM in research mice, as well as the model phenotype, suggesting that the GM represents a major component in experimental reproducibility. Moreover, several recent studies suggest that manipulation of the GM of laboratory mice can substantially improve the predictive power or translatability of data generated in mouse models to the human conditions under investigation. This review provides readers with information related to these various factors and practices, and recommendations regarding methods by which issues with poor reproducibility or translatability can be transformed into discoveries.
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