期刊
MACROMOLECULAR CHEMISTRY AND PHYSICS
卷 222, 期 9, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.202100027
关键词
biopolymers; drug release; hybrids; hydrogels; polysaccharides; silica
资金
- Egyptian Ministry of Higher Education
- Max Planck Society of the Max Planck Partner Group on Colloidal Methods for Multifunctional Materials (CM3-Lab) at the University of Valencia
This work presents an in situ strategy for the synthesis of hybrid sub-millispheres as carriers for encapsulating and controlling the release of hydrophilic pharmaceutical compounds. An organic-inorganic hydrogel is prepared by ionotropic gelation, using chitosan or alginate as biopolymers to generate a scaffold network. The system overcomes the limitations of the ionotropic method for entrapping hydrophilic substances by incorporating nanostructured silica into the polymer matrix.
This work reports an in situ strategy for the synthesis of hybrid sub-millispheres as carriers for encapsulating and controlling the release of hydrophilic pharmaceutical compounds in both neutral and acidic media. An organic-inorganic hydrogel is prepared by ionotropic gelation, and its efficiency for entrapping hydrophilic molecules is investigated. Two biopolymers, namely chitosan or alginate, are used to generate a scaffold network, in which the formation of silica nanoparticles takes place in situ by a sol-gel process. Model hydrophilic molecules (erioglaucine disodium salt and ephedrine hydrochloride) are encapsulated within polymer matrix, and the subsequent release is controlled by tailoring the hybrid network structure. Kinetic studies demonstrate that the release of the active substance is slower in the presence of silica, which increases as well the structural stability of the carrier in both neutral and acidic media. As a result, by incorporating nanostructured silica into the polymer matrix, the presented system overcomes the limitations of the ionotropic method for entrapping hydrophilic substances.
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