期刊
LUMINESCENCE
卷 36, 期 4, 页码 1056-1062出版社
WILEY
DOI: 10.1002/bio.4034
关键词
controllable morphology; hydrothermal method; Tm3+ nanocrystals; upconversion luminescence; beta-NaYF4:Yb-3 (+)
资金
- National Natural Science Foundation of China [21807099]
- Science and Technology Development Foundation of Jilin Province [20150204030YY]
Ytterbium, thulium co-doped beta-NaYF4 upconversion nanocrystals were successfully synthesized using a hydrothermal method with sodium citrate as a capping agent, showing controlled morphology and luminescence efficiency. Incubation with MCF-7 cells resulted in clear upconversion luminescence under 980 nm laser irradiation, making these nanocrystals efficient luminescent probes for diverse biological applications.
Ytterbium, thulium (Yb3+,Tm3+) co-doped beta-NaYF4 upconversion nanocrystals (U-NCs) were synthesized by a convenient hydrothermal method using sodium citrate as a capping agent. X-ray diffraction (XRD) analysis revealed that NCs phase structures were dependent on reaction time. Field-emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) results showed that the morphology of U-NCs could be controlled by adjusting the concentration of sodium citrate added in the hydrothermal reaction. Moreover, the emission spectra of the U-NCs were investigated to evaluate upconversion efficiency. Strong luminescence intensity of the U-NCs was observed after tuned with optimized concentration of sodium citrate. Furthermore, the U-NCs were incubated with MCF-7 cells at 37 degrees C for 24 h. Under irradiation of a 980 nm laser, the upconversion blue emission of the NCs in MCF-7 cells can be clearly observed through a confocal microscope with an upconversion imaging system and high quality upconversion luminescence images can be acquired. Thus, prepared beta-NaYF4:Yb3+,Tm3+ NCs provide us with highly efficient luminescent probes which can be applied for diverse bio-applications.
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