期刊
LIVER INTERNATIONAL
卷 41, 期 7, 页码 1556-1564出版社
WILEY
DOI: 10.1111/liv.14830
关键词
alcohol; alcohol‐ related liver disease; liver fibrosis; metabolic syndrome; population‐ based cohort; transient elastography
资金
- Fondo de Investigacion de Salud - Instituto de Salud Carlos III - Spanish Ministry of the Economy, Industry and Competitiveness [FIS PI18/01330, PI18/00662]
- European Regional Development Fund (ERDF)
- Agencia de gestio d'ajuts Universitaris i de Recerca (AGAUR) [2017- SGR -01281]
Alcohol and metabolic syndrome are common cofactors of liver disease. This study found that metabolic syndrome increases the risk of liver fibrosis in individuals with alcohol consumption, especially in high-risk drinkers. Factors such as male gender, liver enzymes, years of consumption, and metabolic syndrome were associated with liver fibrosis in subjects with alcohol consumption.
Background and aims Alcohol and metabolic syndrome (MS) coexist frequently as cofactors of liver disease. Previous studies suggest a deleterious effect of MS in advanced alcohol-related liver disease (ArLD). However, it is unknow whether MS can increase the risk of liver fibrosis in early stages of ArLD. The aim of this study was to investigate the effect of MS on liver fibrosis in subjects with alcohol consumption from a population-based cohort. Methods The number of subjects include 1760(58%) of 3014 who were randomly selected from the community consumed alcohol and were classified as current drinkers, divided in moderate (n = 1222) or high-risk drinkers (n = 275) (>21 units/week men, >14 units/week women for high-risk drinkers), or former drinkers (n = 263). Liver fibrosis was estimated by measuring liver stiffness(LS) with transient elastography (TE). Results Prevalence of significant LS using cutoff values of TE of 8 and 9.1kPa was increased in high-risk compared with moderate or former drinkers and lifetime abstainers. In subjects with alcohol consumption, LS was associated with male gender, AST, ALT, years of consumption, and MS. In high-risk drinkers, MS and intensity of consumption were the only factors associated with significant LS (OR 3.7 and 4.6 for LS >= 8 kPa and 3.9 and 9.2 kPa for LS >= 9.1 kPa, respectively). Presence of significant liver fibrosis in the liver biopsy was higher among high-risk as compared with moderate or former drinkers. Conclusion MS increases the risk of liver fibrosis in subjects with alcohol consumption. Among high-risk drinkers, only MS and consumption of high amount of alcohol are associated with risk of liver fibrosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据