期刊
LIPIDS IN HEALTH AND DISEASE
卷 20, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12944-021-01433-9
关键词
Polycystic ovary syndrome; Canola oil; Olive oil; Lipid profile; Fatty liver; Polyunsaturated fatty acid; Monounsaturated fatty acid; HOMA-IR; SHBG
This study found that, compared to olive and sunflower oils, consuming canola oil significantly improved the lipid profile, liver function, and HOMA-IR in women with PCOS.
Background: Polycystic Ovarian Syndrome (PCOS) is one of the most common endocrinopathies and metabolic disorders in women during their reproductive years. It is often associated with dyslipidemia and other risk factors of cardiovascular diseases (CVD). This study was aimed to evaluate dietary intervention effects with canola and olive oils compared to sunflower oil on lipid profile and fatty liver severity among women with PCOS. Method: This study was a 10-week intervention including 72 women with PCOS. Patients were randomly assigned to three groups for receiving 25 g/day canola, olive, or sunflower oils for 10 weeks. The primary and secondary outcomes were to assess changes in lipid profile and in fatty liver severity, respectively. Result: At the end of the study, 72 patients with a mean age of 29.31 were analysed. Canola oil consumption resulted in a significant reduction in serum levels of TG (P = 0.002) and TC/HDL (P = 0.021), LDL/HDL (P = 0.047), and TG/HDL (P = 0.001) ratios, however, there was no significant reduction in lipid profile following olive oil consumption. Canola (P < 0.001) and olive oils (P = 0.005) could significantly reduce the fatty liver grade. Moreover, HOMA-IR in both canola (P < 0.001) and olive (P = 0.004) groups was significantly decreased. Conclusion: In total, compared to olive and sunflower oils, significant improvements in lipid profile, liver function, and HOMA-IR were observed following canola oil consumption in women with PCOS.
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