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TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
Vitamin D Inhibits Human Immunodeficiency Virus Type 1 and Mycobacterium tuberculosis Infection in Macrophages through the Induction of Autophagy
Grant R. Campbell et al.
PLOS PATHOGENS (2012)
Phosphodiesterase-4 Inhibition Combined with Isoniazid Treatment of Rabbits with Pulmonary Tuberculosis Reduces Macrophage Activation and Lung Pathology
Selyakumar Subbian et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Linezolid, the first oxazolidinone antibacterial agent
Karen L. Leach et al.
PHARMACEUTICAL SCIENCE TO IMPROVE THE HUMAN CONDITION: WINNERS AND FINALIST CANDIDATES OF THE PRIX GALIEN USA, INTERNATIONAL, AND PRO BONO HUMANITARIAN AWARDS 2010 (2011)
Inhibition of Bacterial Multidrug Resistance by Celecoxib, a Cyclooxygenase-2 Inhibitor
Arunasree M. Kalle et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Molecular Investigation of Resistance to the Antituberculous Drug Ethionamide in Multidrug-Resistant Clinical Isolates of Mycobacterium tuberculosis
F. Brossier et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Characteristic Resistance Mechanism of Mycobacterium tuberculosis to DC-159a, a New Respiratory Quinolone
Jun-ichiro Sekiguchi et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Activity of the Fluoroquinolone DC-159a in the Initial and Continuation Phases of Treatment of Murine Tuberculosis
Zahoor Ahmad et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Identification of SQ609 as a lead compound from a library of dipiperidines
Elena Bogatcheva et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism
Kristin N. Adams et al.
CELL (2011)
Imatinib-Sensitive Tyrosine Kinases Regulate Mycobacterial Pathogenesis and Represent Therapeutic Targets against Tuberculosis
Ruth J. Napier et al.
CELL HOST & MICROBE (2011)
In Silico Subtractive Genomics for Target Identification in Human Bacterial Pathogens
Debmalya Barh et al.
DRUG DEVELOPMENT RESEARCH (2011)
Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients
A. H. Diacon et al.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2011)
Chemical modification of capuramycins to enhance antibacterial activity
Elena Bogatcheva et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2011)
Comparison of clinical isolates and in vitro selected mutants reveals that tlyA is not a sensitive genetic marker for capreomycin resistance in Mycobacterium tuberculosis
Anna Engstrom et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2011)
Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice
Mi-Sun Koo et al.
PLOS ONE (2011)
Probing the Interaction of the Diarylquinoline TMC207 with Its Target Mycobacterial ATP Synthase
Anna C. Haagsma et al.
PLOS ONE (2011)
MEROPENEM/CLAVULANATE AND LINEZOLID TREATMENT FOR EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS
Nicolas Dauby et al.
PEDIATRIC INFECTIOUS DISEASE JOURNAL (2011)
Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis
Wanliang Shi et al.
SCIENCE (2011)
Novel targets in M. tuberculosis: search for new drugs
Gyanu Lamichhane
TRENDS IN MOLECULAR MEDICINE (2011)
Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid - Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs
Selvakumar Subbian et al.
PLOS PATHOGENS (2011)
In Vitro Interactions between New Antitubercular Drug Candidates SQ109 and TMC207
Venkata M. Reddy et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Discovery of dipiperidines as new antitubercular agents
Elena Bogatcheva et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
3D-QSAR in Drug Design - A Review
Jitender Verma et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2010)
rpoB gene mutation profile in rifampicin-resistant Mycobacterium tuberculosis clinical isolates from Guizhou, one of the highest incidence rate regions in China
Ling Chen et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2010)
Polymorphisms Associated with Resistance and Cross-Resistance to Aminoglycosides and Capreomycin in Mycobacterium tuberculosis Isolates from South Korean Patients with Drug-Resistant Tuberculosis
Laura E. Via et al.
JOURNAL OF CLINICAL MICROBIOLOGY (2010)
Evaluation of the MTBDRsl Test for Detection of Second-Line-Drug Resistance in Mycobacterium tuberculosis
Vo Sy Kiet et al.
JOURNAL OF CLINICAL MICROBIOLOGY (2010)
The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin
Radhika Gupta et al.
NATURE MEDICINE (2010)
The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome
Robin E. Stanley et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Addition of PNU-100480 to First-Line Drugs Shortens the time Needed to Cure Murine Tuberculosis
Kathy N. Williams et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)
Promising Antituberculosis Activity of the Oxazolidinone PNU-100480 Relative to That of Linezolid in a Murine Model
K. N. Williams et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Safety, Tolerability, and Pharmacokinetics of PA-824 in Healthy Subjects
Ann M. Ginsberg et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Activity of SQ641, a Capuramycin Analog, in a Murine Model of Tuberculosis
Boris V. Nikonenko et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Molecular Genetics of para-Aminosalicylic Acid Resistance in Clinical Isolates and Spontaneous Mutants of Mycobacterium tuberculosis
Vanessa Mathys et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin
Jae-Min Yuk et al.
CELL HOST & MICROBE (2009)
1α,25-dihydroxyvitamin D3 inhibits matrix metalloproteinases induced by Mycobacterium tuberculosis infection
Anna K. Coussens et al.
IMMUNOLOGY (2009)
Role of embCAB gene mutations in ethambutol resistance in Mycobacterium tuberculosis isolates from India
G. P. S. Jadaun et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2009)
Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans
Thea Morris et al.
JOURNAL OF IMMUNOLOGY (2009)
Synthetic EthR inhibitors boost antituberculous activity of ethionamide
Nicolas Willand et al.
NATURE MEDICINE (2009)
SYSTEMS MICROBIOLOGY - OPINION Drug interactions and the evolution of antibiotic resistance
Pamela J. Yeh et al.
NATURE REVIEWS MICROBIOLOGY (2009)
Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
Vadim Makarov et al.
SCIENCE (2009)
Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis
Jean-Emmanuel Hugonnet et al.
SCIENCE (2009)
Ibuprofen: pharmacology, efficacy and safety
K. D. Rainsford
INFLAMMOPHARMACOLOGY (2009)
Pyrazinamide resistance and pncA gene mutations in Mycobacterium tuberculosis
Pontus Jureen et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Novel drug target strategies against Mycobacterium tuberculosis
Dennis J. Murphy et al.
CURRENT OPINION IN MICROBIOLOGY (2008)
Abl Kinases Regulate Autophagy by Promoting the Trafficking and Function of Lysosomal Components
Gouri Yogalingam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Molecular identification and characterization of rifampicin-resistant Mycobacterium tuberculosis isolates by line probe assay:: an approach for rapid diagnosis of multidrug-resistant tuberculosis
C. Bicmen et al.
LETTERS IN APPLIED MICROBIOLOGY (2008)
The anti-inflammatory drug Diclofenac retains anti-listerial activity in vivo
N. K. Dutta et al.
LETTERS IN APPLIED MICROBIOLOGY (2008)
Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr
Jennifer Baysarowich et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants
Doris Hillemann et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria
Anuradha Alahari et al.
PLOS ONE (2007)
1,25 dihydroxyvitamin D3 modulated cytokine response in pulmonary tuberculosis
M. Vidyarani et al.
CYTOKINE (2007)
Overview of anti-tuberculosis (TB) drugs and their resistance mechanisms
Ruiru Shi et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2007)
Exploring functional genomics for the development of novel intervention strategies against tuberculosis
Helmy Rachman et al.
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2007)
Activity of diclofenac used alone and in combination with streptomycin against Mycobacterium tuberculosis in mice
Noton Kumar Dutta et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2007)
Diarylquinolines target subunit c of mycobacterial ATP synthase
Anil Koul et al.
NATURE CHEMICAL BIOLOGY (2007)
Aspirin and ibuprofen enhance pyrazinamide treatment of murine tuberculosis
Sean T. Byrne et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2007)
A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase
E. Lucile White et al.
JOURNAL OF BIOMOLECULAR SCREENING (2007)
Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria
Susumu Okamoto et al.
MOLECULAR MICROBIOLOGY (2007)
EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets
Lynn G. Dover et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Importance of the efflux pump systems in the resistance of Mycobacterium tuberculosis to Fluoroquinolones and linezolid
I. Escribano et al.
CHEMOTHERAPY (2007)
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice
Makoto Matsumoto et al.
PLOS MEDICINE (2006)
Crystal structure and activity studies of the Mycobacterium tuberculosis β-lactamase reveal its critical role in resistance to β-lactam antibiotics
Feng Wang et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobactetium tuberculosis
Manzour Hernando Hazbon et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Synergistic interactions of SQ109, a new ethylene diamine, with front-line antitubercular drugs in vitro
Ping Chen et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2006)
Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2′-O-methylations in 16S and 23S rRNAs
Shanna K. Johansen et al.
MOLECULAR CELL (2006)
Synthesis and antileprosy activity of some dialkyldithiocarbamates
Vadim Makarov et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2006)
Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis:: Identification of a novel mutation in inhA
ETY Leung et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug
J Jia et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines
M Protopopova et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2005)
A fluoroquinolone resistance protein from mycobacterium tuberculosis that mimics DNA
Subray S. Hegde et al.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2005)
A commercial line probe assay for the rapid detection of rifampicin resistance in Mycobacterium tuberculosis:: a systematic review and meta-analysis -: art. no. 62
M Morgan et al.
BMC INFECTIOUS DISEASES (2005)
Imipenem for treatment of tuberculosis in mice and humans
HF Chambers et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA
SS Hegde et al.
SCIENCE (2005)
Activity of RBx 7644 and RBx 8700, new investigational oxazolidinones, against Mycobacterium tuberculosis infected murine macrophages
R Sood et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2005)
Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models
AJ Lenaerts et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis
K Falzari et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule
V Rao et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
K Andries et al.
SCIENCE (2005)
Innovation - Anti-infectives - Predicting the evolution of antibiotic resistance genes
BG Hall
NATURE REVIEWS MICROBIOLOGY (2004)
Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis
DH Mariam et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)
The structure of a mycobacterial outer-membrane channel
M Faller et al.
SCIENCE (2004)
Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates from Monterrey, Mexico
SV Ramaswamy et al.
JOURNAL OF MEDICAL MICROBIOLOGY (2004)
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide
A Cecchi et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Characterisation of rpsL, rrs and embB mutations associated with streptomycin and ethambutol resistance in Mycobacterium tuberculosis
T Tracevska et al.
RESEARCH IN MICROBIOLOGY (2004)
Molecular basis of intrinsic macrolide resistance in the Mycobacterium tuberculosis complex
K Buriankova et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)
M-tuberculosis persistence, latency, and drug tolerance
JE Gomez et al.
TUBERCULOSIS (2004)
Activity of capuramycin analogues against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellulare in vitro and in vivo
T Koga et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2004)
mymA operon of Mycobacterium tuberculosis:: its regulation and importance in the cell envelope
A Singh et al.
FEMS MICROBIOLOGY LETTERS (2003)
Mutations in putative mutator genes of Mycobacterium tuberculosis strains of the W-Beijing family
ME Rad et al.
EMERGING INFECTIOUS DISEASES (2003)
QSAR -: a piece of drug design
L Pârvu
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2003)
Single nucleotide polymorphisms in genes associated with isoniazid resistance in Mycobacterium tuberculosis
SV Ramaswamy et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)
The effect of drug resistance on the fitness of Mycobacterium tuberculosis
T Cohen et al.
LANCET INFECTIOUS DISEASES (2003)
Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid
Y Zhang et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2003)
In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis that are susceptible or resistant to first-line antituberculous drugs
L Alcala et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)
Regulation of interleukin-8 expression by HMG-CoA reductase inhibitors in human vascular smooth muscle cells
T Ito et al.
ATHEROSCLEROSIS (2002)
Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2
VA Patel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Evolution of drug resistance in Mycobacterium tuberculosis:: Clinical and molecular perspective
SH Gillespie
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)
In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products
L Diomede et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2001)
Mutations at amino acid position 315 of the katG gene are associated with high-level resistance to isoniazid, other drug resistance, and successful transmission of Mycobacterium tuberculosis in The Netherlands
D van Soolingen et al.
JOURNAL OF INFECTIOUS DISEASES (2000)
Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis
AE DeBarber et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
CK Stover et al.
NATURE (2000)
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis
MS Glickman et al.
MOLECULAR CELL (2000)
Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice
E Dubnau et al.
MOLECULAR MICROBIOLOGY (2000)
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