期刊
LEUKEMIA & LYMPHOMA
卷 62, 期 8, 页码 1869-1876出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2021.1894649
关键词
Lymphoma and Hodgkin disease; non-Hodgkin lymphoma; T-cell lymphoma; PTCL; PFS24; prognostication
The study found that PFS24 can predict the survival of Japanese patients with PTCL after CHOP treatment, with its absence being associated with shorter overall survival and poorer response rates.
Peripheral T-cell lymphoma (PTCL) is a group of aggressive lymphomas commonly treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). Progression-free survival at 24 months (PFS24) constitutes a survival predictor for some lymphomas but has not been examined in Asian populations. We retrospectively investigated whether PFS24 was predictive of survival outcomes after CHOP treatment in 73 Japanese patients with PTCL. Patients without PFS24 had shorter median subsequent overall survival (OS) (20.2 vs. 121.0 months, p < 0.001) and shorter median subsequent progression-free survival (5.0 vs. 17.1 months, p = 0.03). Patients without PFS24 had worse overall (62.5% vs. 100%) and complete response rates (45.8% vs. 96.0%) (both p < 0.001). PFS24 absence (hazard ratio: 3.34, p = 0.004) and poor performance status (hazard ratio: 3.17, p = 0.04) were independently predictive of shorter OS. These findings suggest that PFS24 is predictive of survival after CHOP treatment in Japanese patients with PTCL.
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