Ecofriendly Synthesis of Formamidine Derivatives Catalyzed by Al-MCM-41 Mesoporous Materials

Formamidine derivatives have been synthesized in excellent yields at room temperature from primary amine and N,N-dimethylformamide dimethylacetal (DMF-DMA) in the presence of a catalytic amount of Al-MCM-41 synthesized from natural bentonite as silica and aluminum source. The advantages of this method are the use of a cheap, stable, non-toxic, and readily available catalyst, easy work-up, improved yields, and solvent-free conditions.

Automated summary

Formamidine derivatives were synthesized efficiently in this study using a cheap, stable, and non-toxic catalyst, Al-MCM-41, resulting in improved yields and solvent-free conditions.