期刊
LANGMUIR
卷 37, 期 7, 页码 2268-2275出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.0c02698
关键词
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资金
- Leading Initiative for Excellent Young Researchers from the Ministry of Education, Culture, Sports, Science and Technology of Japan [16812285]
- KAKENHI from the Japan Society for the Promotion of Science (JSPS) [20K12055, 18K18157, 16K21034]
This study investigates the physical properties of giant unilamellar vesicles prepared by inverted emulsion and hydration techniques, revealing differences in membrane shape dynamics such as spontaneous curvature, preferred differential area between inner and outer leaflets, and edge tension of membrane pores. The comparison highlights the need to consider the generation technique when studying artificial cell-like model systems.
The giant unilamellar vesicle (GUV) is a basic model of the cell membrane that allows for the modulation and control of membrane shape dynamics, which play essential roles in the functions of living cell membranes. However, to properly use these artificial cell-like model systems, we need to understand their physical properties. GUV generation techniques are key technologies in the synthesis of artificial cell-like model systems. However, it is unclear whether GUVs produced by different techniques have the same physical properties. Here, we have investigated the physical properties of GUVs prepared by inverted emulsion and hydration techniques by examining the membrane shape deformation induced by external stimulation with a nonionic surfactant. We reveal differences in the spontaneous curvature of the membrane, the preferred differential area between the inner and outer leaflets of the membrane, and the edge tension of membrane pores between the GUVs prepared using the two distinct techniques.
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