期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 77, 期 2, 页码 331-338出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glab063
关键词
Alzheimer's disease; Ancestry background; Cognitive aging
资金
- Global Brain Health Institute
- Alzheimer's Association [GBHI_ALZ-18-544305]
- Welcome Trust Health Consequences of Population Change Program [GR066133, GR080002]
This study examines the effects of self-identified race and genetic admixture on dementia prevalence and cognitive performance. The results show no independent association between self-identified race and African ancestry proportion with dementia prevalence and cognitive performance. This suggests that observed differences in dementia prevalence among diverse populations may be primarily influenced by social determinants of health.
Background Population aging will lead to a dramatic increase in dementia prevalence, which will disproportionally affect racial minorities. The presence of racial differences in dementia prevalence has been widely reported in United States, but there are no relevant studies on this topic in low- and middle-income countries. Methods In a cross-sectional survey, 2944 older Cubans were recruited at a community-based level aimed to identify the effects of self-identified race and genetic admixture on cognitive performance. Dementia diagnosis was established using 10/66 Dementia and DSM-IV criteria. APOE-epsilon 4 genotype was determined in 2511 (85%) and genetic admixture was completed for all dementia cases and in a randomly selected sample of cognitive healthy participants (218 dementia cases and 367 participants without dementia). Results The overall prevalence of dementia was 8.7%, without large or statistically significant differences on dementia prevalence (p = .12) by self-identified race. Mean cognitive scores were similar across racial groups (p = .46). After controlling for age, sex, and education, greater proportion of African ancestry was not associated with cognitive performance (p = .17). Conclusions We found no evidence of an independent effect of self-identified race and/or population ancestry on dementia prevalence or cognitive performance. This suggests that observed differences in dementia prevalence among diverse populations may be driven primarily by social determinants of health.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据