4.7 Article

A Biomarker-based Biological Age in UK Biobank: Composition and Prediction of Mortality and Hospital Admissions

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glab069

关键词

Epidemiology; Outcomes; Preventative health care; Risk factors

资金

  1. University of Oxford
  2. UK Medical Research Council
  3. MRC Population Health Research Unit [MC_U137686853, MC_UU_00017/3, MC_ UU_00017/5]
  4. British Heart Foundation
  5. Nuffield Department of Population Health
  6. British Heart Foundation Programme Grant [RG/18/13/33946]
  7. NIHR Oxford Biomedical Research Centre Program
  8. NIHR Collaboration for Leadership in Health Research and Care (CLARHC) Oxford
  9. NIHR Program for Applied Research
  10. NIHR Health Protection Research Unit Gastrointestinal Infections Group
  11. NIHR Diagnostic Evidence Co-operative
  12. UK Medical Research Council [MR/L003120/1]
  13. British Heart Foundation [RG/13/13/30194]
  14. National Institute for Health Research (Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust)
  15. MRC [MR/L003120/1, MC_UU_00017/3, MC_U137686853, MC_UU_00017/5] Funding Source: UKRI

向作者/读者索取更多资源

This study found that lung function, kidney function, reaction time, insulin-like growth factor 1, hand grip strength, and blood pressure were significantly associated with derived biomarker age in a healthy population. The biomarker age explained a large proportion of mortality and hospital admissions effects, outweighing the impact of chronological age.
Background: Chronological age is the strongest risk factor for most chronic diseases. Developing a biomarker-based age and understanding its most important contributing biomarkers may shed light on the effects of age on later-life health and inform opportunities for disease prevention. Methods: A subpopulation of 141 254 individuals healthy at baseline were studied, from among 480 019 UK Biobank participants aged 40-70 recruited in 2006-2010, and followed up for 6-12 years via linked death and secondary care records. Principal components of 72 biomarkers measured at baseline were characterized and used to construct sex-specific composite biomarker ages using the Klemera Doubal method, which derived a weighted sum of biomarker principal components based on their linear associations with chronological age. Biomarker importance in the biomarker ages was assessed by the proportion of the variation in the biomarker ages that each explained. The proportions of the overall biomarker and chronological age effects on mortality and age-related hospital admissions explained by the biomarker ages were compared using likelihoods in Cox proportional hazard models. Results: Reduced lung function, kidney function, reaction time, insulin-like growth factor 1, hand grip strength, and higher blood pressure were key contributors to the derived biomarker age in both men and women. The biomarker ages accounted for >65% and >84% of the apparent effect of age on mortality and hospital admissions for the healthy and whole populations, respectively, and significantly improved prediction of mortality (p < .001) and hospital admissions (p < 1 x 10(-10)) over chronological age alone. Conclusions: This study suggests that a broader, multisystem approach to research and prevention of diseases of aging warrants consideration.

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