4.6 Article

Biological versus mechanical prostheses for aortic valve replacement

期刊

出版社

MOSBY-ELSEVIER
DOI: 10.1016/j.jtcvs.2021.01.118

关键词

Key Words; aortic valve stenosis; survival analysis; long-term adverse effects; heart valve disease

向作者/读者索取更多资源

This study compared the long-term outcomes of biological and mechanical prostheses for aortic valve replacement in patients aged 50 to 65. The results showed no significant difference in long-term survival between the two groups, but patients with mechanical prostheses had a higher risk of major bleeding while those with biological prostheses had a higher reoperation rate. Therefore, for patients in this age group in Spain, biological prostheses may be a reasonable choice.
Objectives: Long-term real-world outcomes are critical for informing decisions about biological (Bio) or mechanical (Mech) prostheses for aortic valve replace-ment, particularly in patients aged between 50 and 65 years. The objective was to compare long-term survival and major adverse cardiac and cardiovascular events (ie, stroke, reoperation, and major bleeding) within this population.Methods: This was a multicenter observational study including all patients aged be-tween 50 and 65 years who underwent an aortic valve replacement because of se-vere isolated aortic stenosis between the years 2000 and 2018. A total of 5215 patients from 27 Spanish hospitals were registered with a follow-up of 15 years. Multivariable analyses, including a 2:1 propensity score matching (1822 Mech and 911 Bio) and competing risks analyses were applied.Results: Bio prostheses were implanted in 19% of patients (n = 992). No significant differences were observed between matched groups in long-term survival (hazard ratio [HR], 1.14; 95% confidence interval [CI], 0.88-1.47; P = .33). Stroke rates were higher for Mech prostheses, but not significant (HR, 0.72; 95% CI, 0.50-1.03; P = .07). Finally, higher rates of major bleeding were found in the Mech group (HR, 0.65; 95% CI, 0.49-0.87; P = .004), whereas reoperation was more frequent among the Bio group (HR, 3.04; 95% CI, 1.80-5.14; P < .001). Bio prostheses increased from 13% in the period from 2000 to 2008 to 24% in 2009 to 2018.Conclusions: Long-term survival was comparable among groups in patients be-tween 50 and 65 years of age. Mech prostheses were associated with a higher risk of major bleeding, whereas Bio prostheses entailed higher reoperation rates. Bio prostheses seem a reasonable choice for patients between 50 and 65 years in Spain. (J Thorac Cardiovasc Surg 2023;165:609-17)

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据