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Michael E. Ostergaard et al.
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Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle
Thazha P. Prakash et al.
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Glucagon-like peptide 1 (GLP-1)
T. D. Mueller et al.
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Jing Lu et al.
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Sebastien Benizri et al.
BIOCONJUGATE CHEMISTRY (2019)
The MemProtMD database: a resource for membrane-embedded protein structures and their lipid interactions
Thomas D. Newport et al.
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Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay
Hans J. Gaus et al.
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Kevin Renault et al.
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Yi-Lynn Liang et al.
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C. Ammala et al.
SCIENCE ADVANCES (2018)
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism
Abhisek Mukherjee et al.
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Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein
Yan Zhang et al.
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Strategies and challenges for the next generation of antibody drug conjugates
Alain Beck et al.
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Joakim E. Swedberg et al.
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Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes
Chris de Graaf et al.
PHARMACOLOGICAL REVIEWS (2016)
Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides
Richard S. Geary et al.
ADVANCED DRUG DELIVERY REVIEWS (2015)
Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides
Michael E. Ostergaard et al.
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Jesper Lau et al.
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Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects
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Sarah Noerklit Roed et al.
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Bikash Manandhar et al.
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Real-time trafficking and signaling of the glucagon-like peptide-1 receptor
Sarah Noerklit Roed et al.
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Thazha P. Prakash et al.
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Characterization of Target mRNA Reduction Through In Situ RNA Hybridization in Multiple Organ Systems Following Systemic Antisense Treatment in Animals
Gene Hung et al.
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The structure and function of the glucagon-like peptide-1 receptor and its ligands
Dan Donnelly
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Targeted estrogen delivery reverses the metabolic syndrome
Brian Finan et al.
NATURE MEDICINE (2012)
Regulation of GIP and GLP1 Receptor Cell Surface Expression by N-Glycosylation and Receptor Heteromerization
Gina M. Whitaker et al.
PLOS ONE (2012)
A Novel Human-Based Receptor Antagonist of Sustained Action Reveals Body Weight Control by Endogenous GLP-1
James T. Patterson et al.
ACS CHEMICAL BIOLOGY (2011)
ViennaRNA Package 2.0
Ronny Lorenz et al.
ALGORITHMS FOR MOLECULAR BIOLOGY (2011)
Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor
Christina Rye Underwood et al.
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Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′O-Methoxyethyl and 2′4′-Constrained 2′O-Ethyl Nucleic Acid Analogues
Punit P. Seth et al.
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Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening
Cassandra Koole et al.
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Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain
Steffen Runge et al.
BIOCHEMISTRY (2007)
Diabetes due to a progressive defect in β-cell mass in rats transgenic for human islet amyloid polypeptide (HIP rat) -: A new model for type 2 diabetes
AE Butler et al.
DIABETES (2004)
The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity
ME Doyle et al.
REGULATORY PEPTIDES (2003)