4.5 Review

Immunotherapy for Merkel cell carcinoma

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Review Dermatology

Current concepts and approaches to merkel cell carcinoma

Marianna Babadzhanov et al.

Summary: Merkel cell carcinoma is a rare and aggressive cutaneous cancer with a neuroendocrine origin, which has been on the rise in incidence. Risk factors include immunosuppression, chronic UV exposure, and old age. Recent studies have shown promising results with PD-1/PD-L1 checkpoint blockade in the management of metastatic MCC.

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Neoadjuvant Nivolumab for Patients With Resectable Merkel Cell Carcinoma in the CheckMate 358 Trial

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Complementing the Cancer-Immunity Cycle

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Review Dermatology

Immune Checkpoint Inhibitors and Beyond: An Overview of Immune-Based Therapies in Merkel Cell Carcinoma

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Merkel cell carcinoma: Clinical outcome and prognostic factors in 351 patients

Linde M. van Veenendaal et al.

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Are there multiple cells of origin of Merkel cell carcinoma?

J. C. Sunshine et al.

ONCOGENE (2018)

Review Oncology

TIGIT: a novel immunotherapy target moving from bench to bedside

Benjamin L. Solomon et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2018)

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Frequent detection of Merkel cell polyomavirus DNA in tissues from 10 consecutive autopsies

Giuseppe Mancuso et al.

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Ipilimumab has efficacy in metastatic Merkel cell carcinoma: a case series of five patients

J. K. Winkler et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2017)

Article Oncology

Merkel Cell Carcinoma: A Population Analysis on Survival

Vishwajith Sridharan et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2016)

Article Oncology

Downregulation of MHC-I Expression Is Prevalent but Reversible in Merkel Cell Carcinoma

Kelly G. Paulson et al.

CANCER IMMUNOLOGY RESEARCH (2014)

Review Immunology

Oncology Meets Immunology: The Cancer-Immunity Cycle

Daniel S. Chen et al.

IMMUNITY (2013)

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Signatures of mutational processes in human cancer

Ludmil B. Alexandrov et al.

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Kaposi sarcoma and Merkel cell carcinoma after autoimmune disease

Kari Hemminki et al.

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Article Medicine, Research & Experimental

Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus

Scott J. Rodig et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Immunology

Age-Specific Seroprevalence of Merkel Cell Polyomavirus, BK Virus, and JC Virus

Raphael P. Viscidi et al.

CLINICAL AND VACCINE IMMUNOLOGY (2011)

Article Immunology

Asymptomatic Primary Merkel Cell Polyomavirus Infection among Adults

Yanis L. Tolstov et al.

EMERGING INFECTIOUS DISEASES (2011)

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Skin cancers associated with autoimmune conditions among elderly adults

E. Lanoy et al.

BRITISH JOURNAL OF CANCER (2010)

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Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients:: the AEIOU features

Michelle Heath et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2008)

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T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus

Masahiro Shuda et al.

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Article Multidisciplinary Sciences

Clonal integration of a polyomavirus in human Merkel cell carcinoma

Huichen Feng et al.

SCIENCE (2008)

Article Oncology

Does chemotherapy improve survival in high-risk Stage I and II Merkel cell carcinoma of the skin?

MG Poulsen et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2006)

Article Oncology

Merkel cell carcinoma: Prognosis and treatment of patients from a single institution

PJ Allen et al.

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Interleukin-12 in anti-tumor immunity and immunotherapy

MP Colombo et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2002)

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Merkel cell carcinoma and HIV infection

EA Engels et al.

LANCET (2002)