Magneto-Controlled Enzyme Activity with Locally Produced pH Changes

Biocatalytic activity of amyloglucosidase (AMG), immobilized on superparamagnetic nanoparticles, is dynamically and reversibly activated or inhibited by applying a magnetic field. The magnetic field triggers aggregation/deaggregation of magnetic particles that are also functionalized with urease or esterase enzymes. These enzymes produce a local pH change in the vicinity of the particles changing the AMG activity.

Automated summary

The biocatalytic activity of amyloglucosidase (AMG), immobilized on superparamagnetic nanoparticles, can be dynamically and reversibly activated or inhibited by applying a magnetic field. The magnetic field triggers aggregation/deaggregation of magnetic particles functionalized with urease or esterase enzymes, resulting in a local pH change that affects the AMG activity.