4.3 Article

Factors associated with progression to infection in methicillin-resistant Staphylococcus aureus-colonized, critically ill neonates

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JOURNAL OF PERINATOLOGY
卷 41, 期 6, 页码 1285-1292

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SPRINGERNATURE
DOI: 10.1038/s41372-021-00944-8

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资金

  1. Children's Discovery Institute of Washington University
  2. St. Louis Children's Hospital
  3. National Institutes of Health/National Institute of Allergy and Infectious Diseases [K23-AI091690]
  4. National Center for Advancing Translational Sciences at the National Institutes of Health [UL1-TR002345]
  5. Agency for Healthcare Research and Quality [R01-HS021736, R01-HS024269]

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This study indicates that progression from MRSA colonization to symptomatic infection is associated with increased morbidity and may be mitigated through decolonization.
Objective To identify factors associated with development of symptomatic infection in infants colonized with methicillin-resistant Staphylococcus aureus (MRSA) in the Neonatal Intensive Care Unit (NICU). Study design This case-control study was performed at St. Louis Children's Hospital NICU from 2009 to 2019. The MRSA-colonized infants who developed symptomatic MRSA infection (cases) were matched 1:3 with MRSA-colonized infants who did not develop infection (controls). Demographics and characteristics of NICU course were compared between groups. Longitudinal information from subsequent hospitalizations was also obtained. Results Forty-two infected cases were compared with 126 colonized-only controls. Cases became colonized earlier in their NICU stay, were less likely to have received mupirocin for decolonization, and had a longer course of mechanical ventilation than controls. Longitudinally, cases had a more protracted NICU course and were more likely to require hospital readmission. Conclusion Progression from MRSA colonization to symptomatic infection is associated with increased morbidity and may be mitigated through decolonization.

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