期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 7, 页码 5129-5141出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00019
关键词
-
资金
- Polish National Science Centre [UMO-2016/21/B/ST5/03382]
The synthesis of four fluorescent diastereoisomeric molecular cages containing cyclotriveratrylene and sucrose moieties connected via naphthalene linkers is reported in this study. These diastereoisomers were found to be selective and efficient receptors for acetylcholine and choline. Among them, compound M-5a showed the highest selectivity value.
The synthesis of four fluorescent diastereoisomeric molecular cages containing cyclotriveratrylene and sucrose moieties connected via the naphthalene linkers is reported. These diastereoisomers were found to be selective and efficient receptors for acetylcholine and choline. Compound P-5a has a better affinity for choline over acetylcholine, while cage M-5a exhibits a higher association constant for acetylcholine over choline. The highest selectivity value was observed for compound M-5a (K-ACh/K-Ch = 3.1). Cages P-5a, P-5b, M-5a, and M-5b were fully characterized by the advanced NMR techniques, and ECD spectroscopy was supported by DFT calculations. The binding constants K-a of these receptors were determined by fluorescence titration experiments in acetonitrile.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据