4.7 Article

The Property-Based Practical Applications and Solutions of Genetically Encoded Acetylcholine and Monoamine Sensors

期刊

JOURNAL OF NEUROSCIENCE
卷 41, 期 11, 页码 2318-2328

出版社

SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1062-19.2020

关键词

acetylcholine; norepinephrine; serotonin; dopamine; neuromodulation; synaptic transmission; superresolution and deconvolution microscopy

向作者/读者索取更多资源

Recent studies have shown that genetically encoded neuromodulatory transmitter sensors, in combination with superresolution and deconvolution microscopy, can visualize neuromodulatory transmission at nanoscale or microscale for the first time. Validation of high-performing sensors has delineated fundamental synaptic properties of neuromodulatory transmission and revealed unexpected fine control and precision in neuromodulation.
Neuromodulatory communication among various neurons and non-neuronal cells mediates myriad physiological and pathologic processes, yet defining regulatory and functional features of neuromodulatory transmission remains challenging because of limitations of available monitoring tools. Recently developed genetically encoded neuromodulatory transmitter sensors, when combined with superresolution and/or deconvolution microscopy, allow the first visualization of neuromodulatory transmission with nanoscale or microscale spatiotemporal resolution. In vitro and in vivo experiments have validated several high-performing sensors to have the qualities necessary for demarcating fundamental synaptic properties of neuromodulatory transmission, and initial analysis has unveiled unexpected fine control and precision of neuromodulation. These new findings underscore the importance of synaptic dynamics in synapse-, subcellular-, and circuit-specific neuromodulation, as well as the prospect of genetically encoded transmitter sensors in expanding our knowledge of various behaviors and diseases, including Alzheimer's disease, sleeping disorders, tumorigenesis, and many others.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据