Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production

Three new guaianolide lactones (1-3) and four new 9-oxonerolidol glucosides (5-8) together with 20 known compounds were isolated from the MeOH extract of the flowers of Chrysanthemum indicum. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data along with acid hydrolysis. Of the isolates, sesquiterpenoids 1-4 and 15 and flavones 17 and 18 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 cells with IC50 values in the range 0.2-27.0 mu M.

Automated summary

Three new guaianolide lactones and four new 9-oxonerolidol glucosides were isolated from the flowers of Chrysanthemum indicum. Some of these compounds showed inhibitory effects on nitric oxide production in cells, indicating their potential pharmacological activities.