Constructive Neutral Evolution 20 Years Later

Evolution has led to a great diversity that ranges from elegant simplicity to ornate complexity. Many complex features are often assumed to be more functional or adaptive than their simpler alternatives. However, in 1999, Arlin Stolzfus published a paper in the Journal of Molecular Evolution that outlined a framework in which complexity can arise through a series of non-adaptive steps. He called this framework Constructive Neutral Evolution (CNE). Despite its two-decade-old roots, many evolutionary biologists still appear to be unaware of this explanastory framework for the origins of complexity. In this perspective piece, we explain the theory of CNE and how it changes the order of events in narratives that describe the evolution of complexity. We also provide an extensive list of cellular features that may have become more complex through CNE. We end by discussing strategies to determine whether complexity arose through neutral or adaptive processes.

Automated summary

The concept of Constructive Neutral Evolution (CNE) suggests that complexity can arise through non-adaptive steps rather than functional or adaptive ones. Despite being around for two decades, many evolutionary biologists seem unaware of this theory. This article explains how CNE changes the narrative order in describing the evolution of complexity, and discusses strategies for determining if complexity arose through neutral or adaptive processes.