期刊
JOURNAL OF MICROBIOLOGY
卷 -, 期 -, 页码 -出版社
MICROBIOLOGICAL SOCIETY KOREA
DOI: 10.1007/s12275-021-0650-3
关键词
RNase regulator; RNase stability; post-translational regulation of RNase; trans-acting regulator; proteolysis
类别
资金
- Chung-Ang University Graduate Research Scholarship
- National Research Foundation of Korea (NRF) [2019R1I1A1A01063517]
- National Research Foundation of Korea [2019R1I1A1A01063517] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
RNA metabolism requires tight regulation to respond to changes in cellular physiology, with ribonucleases playing a crucial role. Living systems have evolved mechanisms to regulate RNase activity at multiple levels, including transcription, post-transcription, post-translation, and cellular localization. Various trans-acting regulators of RNase activity have been discovered in recent years.
RNA metabolism needs to be tightly regulated in response to changes in cellular physiology. Ribonucleases (RNases) play an essential role in almost all aspects of RNA metabolism, including processing, degradation, and recycling of RNA molecules. Thus, living systems have evolved to regulate RNase activity at multiple levels, including transcription, post-transcription, post-translation, and cellular localization. In addition, various trans-acting regulators of RNase activity have been discovered in recent years. This review focuses on the physiological roles and underlying mechanisms of trans-acting regulators of RNase activity.
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