期刊
JOURNAL OF MEDICINAL FOOD
卷 24, 期 9, 页码 925-933出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2020.0122
关键词
fatty acids; phospholipids; polyphenols; pomegranate juice
资金
- Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-68/2020-14/200015]
The study demonstrated that short-term consumption of dietary doses of pomegranate juice had beneficial effects on blood pressure, lipid metabolism, and oxidative stress markers in overweight patients. These effects included a decrease in diastolic blood pressure, LDL cholesterol, and aminotransferase, as well as changes in fatty acid levels and desaturase activity.
Pomegranate juice (PJ) has potential positive effects in patients with metabolic disturbances due to a high content of polyphenols. The objective of this study was to evaluate effects of a 2-week consumption of dietary doses of PJ on blood pressure, lipid metabolism, and oxidative stress markers in overweight patients with dyslipidemia. Twenty-four patients, 8 males and 16 females, 40-60 years of age, with established overweight and dyslipidemia were randomly assigned into intervention group, who consumed 300 mL of PJ daily for 2 weeks, or control group. After 2 weeks of juice intake, intervention group had significantly lower diastolic blood pressure, low-density lipoprotein cholesterol, aminotransferase, and activity of glutathione peroxidase. Furthermore, patients who consumed PJ had reduced percentage of docosahexaenoic acid (22:6n-3, DHA) in plasma phospholipids and increased estimated activity of stearoyl-CoA desaturase. In erythrocytes, we found a significant increase in the levels of dihomo-gamma- linolenic acid (20:3n-6, DGLA) and DHA, as well as in estimated activity of Delta 6 desaturase, and a decrease in estimated activity of Delta 5 desaturase. These results show that even a short-term consumption of dietary doses of PJ exerts beneficial effects and affects lipid metabolism in overweight patients with dyslipidemia.
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