4.7 Article

FLT3 Inhibitors in Acute Myeloid Leukemia: Challenges and Recent Developments in Overcoming Resistance

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Hematology

Tyrosine kinase inhibitors for acute myeloid leukemia: A step toward disease control?

Juan Eduardo Megias-Vericat et al.

BLOOD REVIEWS (2020)

Article Chemistry, Medicinal

Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Chemistry, Medicinal

Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase

Daniela Angst et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Medicine, Research & Experimental

Targeting AML-associated FLT3 mutations with a type I kinase inhibitor

LaQuita M. Jones et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Multidisciplinary Sciences

Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction

Mingzhu Yin et al.

NATURE COMMUNICATIONS (2020)

Article Hematology

Gilteritinib: potent targeting of FLT3 mutations in AML

Mark Levis et al.

BLOOD ADVANCES (2020)

Review Oncology

Advancing treatment of acute myeloid leukemia: the future of FLT3 inhibitors

Amro Elshoury et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2019)

Review Biochemistry & Molecular Biology

New Targeted Agents in Acute Myeloid Leukemia: New Hope on the Rise

Stephan R. Bohl et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Chemistry, Medicinal

Quizartinib (AC220): a promising option for acute myeloid leukemia

Fang Zhou et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2019)

Review Oncology

Clinical considerations for the use of FLT3 inhibitors in acute myeloid leukemia

Taylor M. Weis et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2019)

Article Cell Biology

Overcoming adaptive therapy resistance in AML by targeting immune response pathways

Katelyn Melgar et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Chemistry, Medicinal

Discovery of 4-piperazinyl-2-aminopyrimidine derivatives as dual inhibitors of JAK2 and FLT3

Yingxiu Li et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Chemistry, Medicinal

Discovery of an Orally Available Janus Kinase 3 Selective Covalent Inhibitor

Liyang Shi et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

Haijiao Zhang et al.

NATURE COMMUNICATIONS (2019)

Review Chemistry, Multidisciplinary

Structure-based design of targeted covalent inhibitors

Richard Lonsdale et al.

CHEMICAL SOCIETY REVIEWS (2018)

Article Chemistry, Medicinal

Discovery of the selective and efficacious inhibitors of FLT3 mutations

Yanle Zhi et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Biotechnology & Applied Microbiology

Kinase inhibitors: the road ahead

Fleur M. Ferguson et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Oncology

Clinical development of CDK4/6 inhibitor for breast cancer

Hiroji Iwata

BREAST CANCER (2018)

Article Biochemistry & Molecular Biology

Melatonin Can Strengthen the Effect of Retinoic Acid in HL-60 Cells

Olga Krestinina et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Medicine, General & Internal

Acute myeloid leukaemia

Nicholas J. Short et al.

LANCET (2018)

Review Biochemistry & Molecular Biology

Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia: The Path to Least Resistance

Dilana Staudt et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Chemistry, Multidisciplinary

Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion

George M. Burslem et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Article Oncology

Mechanisms of Resistance to FLT3 Inhibitors and the Role of the Bone Marrow Microenvironment

Gabriel Ghiaur et al.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2017)

Review Biochemistry & Molecular Biology

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

Russel J. Reiter et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Oncology

Syk inhibitors in clinical development for hematological malignancies

Delong Liu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

Article Chemistry, Medicinal

Discovery of an Inhibitor of the Proteasome Subunit Rpn11

Christian Perez et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Oncology

Acute Myeloid Leukemia, Version 3.2017

Margaret R. O'Donnell et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2017)

Review Oncology

FLT3 Inhibitors in Acute Myeloid Leukemia: Current Status and Future Directions

Maria Larrosa-Garcia et al.

MOLECULAR CANCER THERAPEUTICS (2017)

Article Medicine, General & Internal

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

R. M. Stone et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Hematology

Midostaurin approved for FLT3-mutated AML

Mark Levis

Review Oncology

Antibody-drug conjugates for cancer therapy

Anish Thomas et al.

LANCET ONCOLOGY (2016)

Article Oncology

Midostaurin, bortezomib and MEC in relapsed/refractory acute myeloid leukemia

Alison R. Walker et al.

LEUKEMIA & LYMPHOMA (2016)

Article Biochemistry & Molecular Biology

Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML

O. Lindblad et al.

ONCOGENE (2016)

Review Medicine, General & Internal

Acute Myeloid Leukemia

Hartmut Doehner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Cell Biology

Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia

Yiting Lim et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Article Medicine, Research & Experimental

Metformin inhibits the proliferation of A431 cells by modulating the PI3K/Akt signaling pathway

Yingshan Liu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2015)

Article Multidisciplinary Sciences

Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia

Alexa S. Green et al.

SCIENCE ADVANCES (2015)

Review Biochemistry & Molecular Biology

The aurora kinases in cell cycle and leukemia

B. Goldenson et al.

ONCOGENE (2015)

Article Oncology

SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia

Alexandre Puissant et al.

CANCER CELL (2014)

Article Hematology

Sorafenib plus all-trans retinoic acid for AML patients with FLT3-ITD and NPM1 mutations

Sarah Guenounou et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2014)

Article Multidisciplinary Sciences

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

Catherine C. Smith et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

Chunaram Choudhary et al.

MOLECULAR CELL (2009)

Review Chemistry, Medicinal

Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitors

Jeffrey Jie-Lou Liao

JOURNAL OF MEDICINAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

MG Mohi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain

J Griffith et al.

MOLECULAR CELL (2004)

Review Oncology

The role of FLT3 in haematopoietic malignancies

DL Stirewalt et al.

NATURE REVIEWS CANCER (2003)

Review Hematology

The roles of FLT3 in hematopoiesis and leukemia

DG Gilliland et al.

Article Hematology

Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

FM Abu-Duhier et al.

BRITISH JOURNAL OF HAEMATOLOGY (2001)