期刊
JOURNAL OF MEDICAL INTERNET RESEARCH
卷 23, 期 2, 页码 -出版社
JMIR PUBLICATIONS, INC
DOI: 10.2196/23441
关键词
clinical trials; COVID-19; health care worker; motivation; personnel; pre-exposure; professional practice; prophylaxis; SARS-CoV-2; volunteers; web-based survey; workplace safety
Health care workers chose to participate in the MeCOVID and EPICOS trials mainly to contribute to scientific knowledge and to avoid SARS-CoV-2 infection. Safety considerations outweighed efficacy when choosing between the two trials.
Background: In April 2020, two independent clinical trials to assess SARS-CoV-2 prophylaxis strategies among health care workers were initiated at our hospital: MeCOVID (melatonin vs placebo) and EPICOS (tenofovir disoproxil/emtricitabine vs hydroxychloroquine vs combination therapy vs placebo). Objective: This study aimed to evaluate the reasons why health care workers chose to participate in the MeCOVID and EPICOS trials, as well as why they chose one over the other. Methods: Both trials were offered to health care workers through an internal news bulletin. After an initial screening visit, all subjects were asked to respond to a web-based survey. Results: In the first month, 206 health care workers were screened and 160 were randomized. The survey participation was high at 73.3%. Health care workers cited to contribute to scientific knowledge (n=80, 53.0%), followed by to avoid SARS-CoV-2 infection (n=33, 21.9%) and the interest to be tested for SARS-CoV-2 (n=28, 18.5%), as their primary reasons to participate in the trials. We observed significant differences in the expected personal benefits across physicians and nurses (P=.01). The vast majority of volunteers (n=202, 98.0%) selected the MeCOVID trial, their primary reason being their concern regarding adverse reactions to treatments in the EPICOS trial (n=102, 69.4%). Conclusions: Health care workers' reasons to participate in prophylaxis trials in an acute pandemic context appear to be driven largely by their desire to contribute to science and to gain health benefits. Safety outweighed efficacy when choosing between the two clinical trials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据