期刊
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
卷 35, 期 25, 页码 5346-5353出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14767058.2021.1879041
关键词
Antibiotics; cesarean delivery; quality improvement; surgical site infection; vaginal cleansing
By implementing vaginal cleansing, the surgical site infection rate was successfully reduced by 33%, from 22.8% to 15.2%. The addition of azithromycin did not lead to a further decrease in infection rate. Compliance rates for vaginal cleansing and azithromycin increased over time, and the postpartum stay length decreased significantly.
Objective We aimed to decrease our surgical site infection (SSI) rate by 30% by sequential implementation of vaginal cleansing and azithromycin for women who underwent a cesarean delivery (CD) after having labored or experienced rupture of membranes. Methods This is a quality improvement project that assessed the stepwise implementation of two interventions within three time periods: (1) 12 months prior to implementation of either intervention; (2) 14 months of vaginal cleansing as infection prophylaxis; (3) 16 months of vaginal cleansing and azithromycin as infection prophylaxis. The primary outcome measure was the SSI as defined by the Center for Disease Control and Prevention and analyzed by control charts. The process measures were compliance rates of vaginal cleansing and azithromycin. Significance was detected by rules for determining a special cause variation. This study followed the SQUIRE 2.0 guidelines for reporting on quality improvement. Results There were 1033 patients included from the three study periods. The total rate of SSI decreased from 22.8% to 15.2% after implementing vaginal cleansing. Special cause variation was detected with an 8-point shift starting 4 months after implementation of vaginal cleansing. This decrease was sustained during the following 26 months. Adding azithromycin did not significantly lower the SSI rate further. When examined separately, deep SSI (p = .009) and endometritis (p = .001) significantly decreased in the post-intervention periods. Pre-operative vaginal cleansing compliance rose to 74%, and then further increased to 85% 1 year after implementation. Azithromycin compliance rose to 75%. Total length of postpartum stay decreased over the study periods from 3.5 +/- 1.4 days to 3.2 +/- 0.8 days (p = .001). Conclusion In this quality improvement study, implementation of vaginal cleansing decreased the SSI rate by 33%, from 22.8% to 15.2%. The addition of azithromycin did not result in any additional change in SSI rate.
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