Dendritic cells transduced with TIPE-2 recombinant adenovirus induces T cells suppression

Introduction TIPE-2 has been identified as a negative regulator of both innate and adaptive immunity and is involved in several inflammatory diseases. However, the role of immune suppression of dendritic cells (DCs) transduced with TIPE-2 has not been well studied. Methods In this study, DCs were transduced with TIPE-2 recombinant adenovirus, and then were cocultured with allogeneic CD4+ or CD8 + T cells. The proliferation, cytokine production and activation marker levels of CD4+ or CD8 + T cell were detected. Results The data demonstrated that T cell proliferation, cytokine production and activation marker levels were attenuated after treated with TIPE-2 transduced DCs. Conclusions These results suggested that TIPE-2 transduced DCs are capable of inducing allogeneic CD4+ or CD8 + T cell immune suppression, which provide a promising way for the therapeutical strategies of transplantation or autoimmune diseases.

Automated summary

The study showed that immune suppression of allogeneic CD4+ or CD8+ T cells can be induced by TIPE-2 transduced dendritic cells, leading to reduced T cell proliferation, cytokine production, and activation marker levels. These results suggest that TIPE-2 transduced DCs could be a promising approach for therapeutic strategies in transplantation or autoimmune diseases.