相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。
Article
Immunology
Melinda M. Pettigrew et al.
Summary: Pneumonia is a heterogeneous and complex disease that remains a leading source of disease and death globally, despite advancements in diagnostics, treatment, and prevention. Current methods for prevention include vaccines and antibiotic treatment, but the threat of antimicrobial resistance poses challenges to these treatments. Additionally, the emergence of SARS-CoV-2 has significantly shifted the epidemiology of pneumonia since December 2019, highlighting the need for a broader conceptual framework to address the pathogenesis of pneumonia.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Ylaine Gerardin et al.
Summary: The transfer of live gut microbes may revolutionize the treatment of various diseases, with fecal microbiota transplantation showing early success in certain infections. The development of microbiome drugs is now being driven by these clinical advances, although challenges remain in terms of safety, consistency, and delivery.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Artur Sargun et al.
Summary: The review outlines the use of siderophore-mediated iron acquisition in Gram-negative bacteria, providing a foundation for the conceptualization and development of approaches to prevent and treat bacterial infections. Differences in the siderophore-based iron uptake mechanisms between pathogenic Enterobacteriaceae and commensal microbes may lead to the development of selective Trojan-horse antimicrobials and immunization strategies that will not harm the host microbiota.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Robert Thanert et al.
Summary: Decades of research have yet to fully understand the pathophysiology of necrotizing enterocolitis (NEC), a severe pediatric gastrointestinal disorder. Evidence suggests that host-microbiota interactions play a crucial role in NEC development. Greater understanding of the preterm infant microbiome could lead to enhanced diagnostics, treatments, and preventive measures for NEC.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Conan Y. Zhao et al.
Summary: The study found that models trained on whole-microbiome quantitation outperformed models trained only on pathogen quantitation in lung infections in people with cystic fibrosis. The most accurate models retained key pathogens and nonpathogen taxa as important predictors of lung health.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Gregory L. Damhorst et al.
Summary: There is increasing recognition of the significance of the gut microbiome in human health and disease. Traditional and modern technologies have advanced our knowledge in this field, but standardizing the language and metrics for characterizing the microbiome is still a work in progress. The capabilities of gut microbiome-based diagnostics are promising for clinical applications, with selected examples demonstrating their potential impact.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
William D. Miller et al.
Summary: Sepsis-induced alterations in the gut microbiome can lead to organ dysfunction, prompting research into microbiota-directed interventions to address this issue.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Laurel A. Lagenaur et al.
Summary: Maintaining a dominant Lactobacillus species in the vaginal microbiota is crucial for preventing infections and supporting gynecologic health. Specific species like Lactobacillus crispatus are associated with preventing dysbiosis-related diseases. Therefore, replenishing the imbalanced microbiota with protective lactobacilli like CTV-05 may help in preventing recurrent BV.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Andrew Nishimoto et al.
Summary: Bacterial, fungal, and helminthic species within the microbiome of mammalian hosts have significant effects on health and disease. Pathogenic viruses have evolved to interact with and potentially exploit or evade the microbiome during infection. Recent research has highlighted both synergistic and antagonistic interactions between the microbiome and pathogenic viruses, showcasing the complexity of their relationship.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Alexander D. Ethridge et al.
Summary: Intercellular communication is mostly mediated through ligand-receptor binding and signaling for both host cells and microbial cells. Nonprotein metabolites play a significant role in mucosal immunity, and the list of potential immunomodulatory molecules derived from the microbiome is expanding. Various microbial signals, including short-chain fatty acids, bile acids, and histamine, contribute to immunomodulation.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Colleen M. Pike et al.
Summary: Clostridioides difficile is an urgent antimicrobial-resistant bacterium causing a range of diseases, and commensal gut microbes play a critical role in providing resistance against it, potentially serving as a non-antibiotic alternative therapy for prevention and treatment.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Winston E. Anthony et al.
Summary: This review discusses the gut as a reservoir for antimicrobial resistance and pathogen colonization, with a focus on beta-lactam and plasmid-mediated quinolone resistance. It also explores the use of functional metagenomics and long-read sequencing technologies to detect and understand antimicrobial resistance genes within the gut microbiome, as well as the potential for future microbiome-directed methods for detecting and preventing infections.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Quinten R. Ducarmon et al.
Summary: The article discusses the opportunities and challenges of using Live biotherapeutic products (LBPs) to restore gut colonization resistance and control expansion of resistant strains, focusing on commercial fecal microbiota transplantation-like products and defined bacterial consortia.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Susan Tuddenham et al.
Summary: The unique composition and function of the cervicovaginal microbiota are associated with protection against and risk for sexually transmitted infections (STI), while less is known about the interaction between penile microbiota and STIs in men. This review briefly discusses the current understanding of these microbiota and their role in select STIs, as well as strategies for manipulating genital microbiota to optimize protection against STIs, highlighting major research gaps and proposing a framework for future studies.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Jonathan L. Golob et al.
Summary: Antimicrobial resistance has become a global medical challenge, and despite various measures taken, the challenge continues to grow. The gut microbiome plays a crucial role in both the risk of colonization by antibiotic-resistant organisms and defense against infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
C. M. Rooney et al.
Summary: There are three different approaches to protecting the gut microbiome: highly targeted antibiotics, antibiotic destruction, and antibiotic binding. Each approach has the potential to prevent the off-target effects of antibiotics on the gut microbiome.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Kristina E. Rudd et al.
Review
Immunology
Martina Sassone-Corsi et al.
JOURNAL OF IMMUNOLOGY
(2015)
Letter
Gastroenterology & Hepatology
Faming Zhang et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2012)
Review
Microbiology
M. Indriati Hood et al.
NATURE REVIEWS MICROBIOLOGY
(2012)
Review
Biochemistry & Molecular Biology
Robert A. Britton et al.
TRENDS IN MICROBIOLOGY
(2012)
