期刊
JOURNAL OF INFECTIOUS DISEASES
卷 226, 期 3, 页码 441-452出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiab048
关键词
acute infection; direct-acting antivirals; hepatitis C virus; proximity extension assay; soluble inflammatory milieu
资金
- Deutsche Forschungsgemeinschaft (DFG) [158989968, SFB 900, SFB738]
- German Centre for Infection Research (DZIF)
- University of Duisburg-Essen
Patients with acute hepatitis C infection showed significant alterations in soluble inflammatory mediators compared to chronic hepatitis patients and healthy controls. Early treatment with DAAs partially normalized these changes, but long-lasting imprints of HCV remained.
Background Treatment with direct-acting antivirals (DAAs) in patients with chronic hepatitis C infection leads to partial restoration of soluble inflammatory mediators (SIMs). In contrast, we hypothesized that early DAA treatment of acute hepatitis C virus (HCV) with DAAs may normalize most SIMs. Methods In this study, we made use of a unique cohort of acute symptomatic hepatitis C patients who cleared HCV with a 6-week course of ledipasvir/sofosbuvir. Plasma samples were used for proximity extension assay measuring 92 proteins. Results Profound SIM alterations were observed in acute HCV patients, with marked upregulation of interleukin (IL)-6 and CXCL-10, whereas certain mediators were downregulated (eg, monocyte chemoattractant protein-4, IL-7). During treatment and follow-up, the majority of SIMs decreased but not all normalized (eg, CDCP1, IL-18). Of note, SIMs that were downregulated before DAA treatment remained suppressed, whereas others that were initially unchanged declined to lower values during treatment and follow-up (eg, CD244). Conclusions Acute hepatitis C was associated with marked changes in the soluble inflammatory milieu compared with both chronic hepatitis patients and healthy controls. Whereas early DAA treatment partly normalized this altered signature, long-lasting imprints of HCV remained.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据