Assessing hemodynamic response to submaximal exercise in pulmonary arterial hypertension patients using an implantable hemodynamic monitor

Pulmonary arterial hypertension (PAH) is a chronic, progressive disease that is incurable, even with effective therapy. Long-term outcome in PAH is best preserved by targeting hemodynamic improvements to reduce risk of subsequent right ventricular (RV) failure. Methods that can assess RV adaptation to stress have important implications to better understand an individual's physiology and may play a pivotal role in guiding therapy in PAH. In this novel pilot study, we evaluate the feasibility of monitoring hemodynamic response to 6-minute walk distance in patients with PAH using the CardioMEMS HF System. J Heart Lung Transplant 2021;40:430 & minus;434 (c) 2021 International Society for Heart and Lung Transplantation. All rights reserved.

Automated summary

PAH is a chronic, progressive disease that is incurable even with effective therapy. Targeting hemodynamic improvements to reduce the risk of subsequent RV failure is key to preserving long-term outcomes in PAH. Assessing RV adaptation to stress plays a pivotal role in guiding therapy for PAH patients.