期刊
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
卷 35, 期 3, 页码 280-292出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0891988721993545
关键词
depression; apathy; progressive supranuclear palsy
Depression and apathy are common in PSP patients, with depression prevalence influenced by apathy and most apathy studies relying on screening question methods.
Depression and apathy can be significant problems in progressive supranuclear palsy (PSP). Using PRISMA guidelines, this systematic review examined prevalence estimates for depression and apathy in PSP, and, how different methods of definition may influence results. 29 studies meeting inclusion/exclusion criteria were identified: 12 on depression, 9 on apathy, and 8 on both. Studies were stratified according to whether a diagnostic criteria, rating scale or screening question methodology was employed. The weighted mean prevalence was 59.7% for depression (sample size = 473) and 58.3% for apathy (sample size = 858). Results for depression using diagnostic criteria or rating scales were similar whereas screening questions were associated with considerable inconsistency. Depression prevalence appeared to be influenced by apathy but not somatic symptoms. Most apathy studies relied only on a screening question method. Depression and apathy are common in PSP but there is a need for consensus on how they are defined (both tools and cut-off scores). In particular, more studies probing apathy in greater detail than a simple screening question are required.
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