4.3 Article

Baseline omega-3 level is associated with nerve regeneration following 12-months of omega-3 nutrition therapy in patients with type 1 diabetes

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出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.jdiacomp.2020.107798

关键词

Omega-3; Diabetes; Diabetic neuropathy; Corneal nerve fibre length

资金

  1. Canadian Diabetes Association [OG-2-13-4093-VB]
  2. CIHR Post-Doctoral Fellowship

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This study found an association between low plasma DHA and prevalent DSP in patients with T1D, while n-3 therapy increased blood n-3 levels and promoted nerve regeneration, with higher baseline n-3 levels correlating with greater nerve regeneration.
Aim: Omega-3 (n-3) polyunsaturated fatty-acids are essential for the development and maintenance of nerve function, but the relationship of plasma n-3 to the presence of diabetic distal-symmetric-polyneuropathy (DSP) and the effect of n-3 therapy on plasma levels and small nerve fibre morphology in T1D are unknown. Methods: Participants with T1D (n 40, 53% female, aged (mean +/- SD) 48 +/- 14 years, BMI 28.1 +/- 5.8 kg/m(2), diabetes duration 27 +/- 18 years), 23 of whom had DSP, took seal-oil (10 mL/day; 750 mg eicosapentaenoic acid (EPA), 560 mg docosapentaenoic acid (DPAn -3), and 1020 mg docosahexaenoic acid (DHA)) for 12-months in a single-arm open-label study. The improvement in corneal nerve fibre length (CNFL) (primary outcome) was previously reported. In this secondary analysis, plasma n -3s were measured at baseline, 4, 8 and 12-months. Results: At baseline, participants with DSP had lower DHA than those without (1.73 +/- 0.89 vs. 227 +/- 0.70%, p = 0.049). Twelve-months seal-oil therapy increased mean plasma EPA by 185%, DPA by 29%, DHA by 79% (p < 0.001) and CNFL by 29% (p = 0.001). Change in CNFL was positively associated with higher baseline total n-3 (Spearman's correlation coefficient r = 0.41, p = 0.013). DPA (r = 0.33, p = 0.047) and DHA (r = 0.42, p = 0.012). Conclusion: In conclusion, low plasma DHA was associated with prevalent DSP, n-3 therapy increased blood n-3 levels and higher baseline n-3s were associated with greater nerve regeneration. (C) 2020 Elsevier Inc. All rights reserved.

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