期刊
JOURNAL OF DAIRY SCIENCE
卷 104, 期 4, 页码 4044-4055出版社
ELSEVIER SCIENCE INC
DOI: 10.3168/jds.2020-19467
关键词
population genetics; genome-wide association study; Lactobacillus delbrueckii ssp. bulgaricus; acid production; dairy product
资金
- National Natural Science Foundation of China [31430066, 31622043, 31972095]
- China Agriculture Research System [CARS-36]
- National Natural Science Foundation of Inner Mongolian Autonomous Region [2019ZD06]
The study investigated the industrial potential of Lactobacillus delbrueckii ssp. bulgaricus through population genomics and GWAS analysis, revealing a significant association between its genetic background and acid production capacity, particularly the l-lactate dehydrogenase gene. The findings provide potential targets for further research, development, and use of lactic acid bacteria in the dairy industry.
Lactobacillus delbrueckii ssp. bulgaricus is one of the most commonly used starter cultures for yogurt production. However, how its genetic background affects acid production capacity is unclear. This study investigated the industrial potential of L. delbrueckii ssp. bulgaricus using population genomics and GWAS analysis. To meet our goal, population genetics and functional genomics analyses were performed on 188 newly sequenced L. delbrueckii ssp. bulgaricus strains isolated from naturally fermented dairy products together with 19 genome sequences retrieved from the NCBI database. Four distinct clusters were identified, and they were correlated with the geographical sites where the samples were collected. The GWAS analysis about acidification fermentation results with sucrose-fortified reconstituted skim milk revealed a significant association between l-lactate dehydrogenase (lldD; Ldb2036) and the bacterial acid production rate. Our study has broadened the understanding of the population structure and genetic diversity of L. delbrueckii ssp. bulgaricus by identifying potential targets for further research, development, and use of lactic acid bacteria in the dairy industry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据