4.8 Article

Protective and healing effects of apoptotic mimic-induced M2-like macrophage polarization on pressure ulcers in young and middle-aged mice

期刊

JOURNAL OF CONTROLLED RELEASE
卷 330, 期 -, 页码 705-714

出版社

ELSEVIER
DOI: 10.1016/j.jconrel.2020.12.052

关键词

Pressure ulcer; M2 macrophage; Macrophage polarization; Apoptotic cell mimic; Phosphatidylserine-containing liposome

资金

  1. Kowa Life Science Foundation
  2. AMED [JP20fk0210044]
  3. JSPS KAKENHI [JP18K12091, JP17K01386]

向作者/读者索取更多资源

The study suggests that phosphatidylserine-containing liposomes can promote the generation of M2-like macrophages to protect against pressure ulcer formation and accelerate healing. Older animals demonstrate slower wound healing, but PSL treatment significantly accelerates wound closure.
Pressure ulcers (PUs) have no cure and are of significant health and economic concern worldwide, owing to the increasing population of elderly individuals at high risk for PU and who have impaired tissue repair. Macrophages play a pivotal role in PU development and healing. Imbalances between M1 (inflammatory) and M2 (anti-inflammatory/reparative) macrophages result in delayed resolution of inflammation and wound healing. We hypothesized that M1-to-M2 macrophage polarization mediated by artificial apoptotic cell mimics, phosphatidylserine-containing liposomes (PSLs), would protect against PU formation and accelerate PU healing in young (2-month-old) and middle-aged (12-month-old) mice. We used a clinically relevant murine model of ischemia-reperfusion-induced PU. Middle-aged mice displayed the delayed wound healing associated with increased inflammation, decreased collagen deposition, reduced angiogenesis, and delayed wound closure relative to their younger counterparts. PSL treatment significantly inhibited PU formation and promoted tissue remodeling in both age groups. These effects were mediated by increased M1-to-M2 macrophage polarization, induced by the PSLs. Thus, this study suggests, for the first time, that PSL-induced M2-like macrophage polarization is a promising strategy to protect against PU formation and promote PU repair in human patients of all ages.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据