期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 593, 期 -, 页码 424-433出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2021.02.098
关键词
Mesoporous silica nanoparticles; Transferrin; Stimuli responsive; Water-insoluble drug; Targeted drug delivery
资金
- National Key R&D Program of China [2018YFC1602301, 2018YFA0209402]
- National Natural Science Foundation of China [21373059]
- Natural Science Foundation of Zhejiang Province [LQ21B030001]
- Foshan Science and Technology Innovation Project [2017IT100121]
This study developed an intelligent nanocarrier drug delivery system that can highly load water-insoluble drugs and possess desirable tumor-targeting properties for cancer therapy. The nanocarriers exhibit accumulation ability on tumor cells both in vitro and in vivo, showing great promise for the efficient delivery of hydrophobic drugs and tumor treatment.
The efficacy of hydrophobic chemotherapy drugs in cancer treatment is often hampered by their poor solubility in the physiological environment, which causes their low delivery efficiency in the body. This manuscript develops an intelligent nanocarrier (similar to 100 nm) drug delivery system that can highly load a water-insoluble drug, and possesses desirable tumor-targeting properties for cancer therapy. In this system, highly porous silica nanoparticles (pore volume similar to 1.4 cm(3) g(-1)) with a dendritic pore structure (denoted as DMSN) are applied as a matrix for drug loading. A facile, vacuum rotary evaporation mediated casting method is applied to quantitatively load a high content of a hydrophobic drug (i.e., paclitaxel) in the DMSN matrix. A thiol-modified poly(methacrylic acid) (denoted as PMAsh) shell is then assembled and crosslinked via disulfide bonds on the particle surface to improve the dispersibility of the particles in an aqueous environment. After functionalization of the PMAsh shell with the targeting ligand transferrin (Tf), the nanocarriers exhibit accumulation ability on tumor cells, both in vitro and in vivo. Combining the fascinating properties of high drug-loading, excellent colloidal stability, low cytotoxicity, targeting ability and glutathione-responsive PMAsh shell deconstruction properties, the nanocarriers described here hold great promise for the efficient delivery of hydrophobic drugs and tumor treatment. (C) 2021 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据