期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 596, 期 -, 页码 312-323出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2021.02.107
关键词
Peptide; Nanofibers reinforce; Injectable hydrogel; Antibacterial and hemostatic properties; Chronic wound healing
资金
- National Key Research and Development Program of China [2017YFB0309001]
- Natural Science Foundation of Shanghai [18ZR1400400, 18ZR1400500]
The peptide modified nanofibers reinforced hydrogel designed by Schiff base dynamic crosslinking not only maintains a healthy wound microenvironment, but also greatly enhances the stability and mechanical strength of the hydrogel.
The chronic wounds often hinder wound healing resulting from infection; thus, an ideal wound dressing should be able to maintain a healthy wound microenvironment. Herein, peptide modified nanofibers reinforced hydrogel has been designed by Schiff base dynamic crosslinking. The incorporation of the nanofibers into the hydrogel extremely enhances the stability and mechanical strength of the hydrogel. Taking advantage of the feature, the reinforced hydrogel can restore its original shape while suffering the various external forces on the hydrogel-covered irregular shape wounds. The peptide modified nanofibers reinforced hydro gel (NFRH) not only possesses injectable and self-healing properties, but also inherent antibacterial and hemostatic properties, which can eradicate the bacterial biofilms and induce blood cells and platelets aggregation and finally accelerate the chronic wound healing process. The peptide modified nanofibers reinforced hydrogel has enormous potential to be novel dressing for chronic wounds healing clinically. (c) 2021 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据