期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 59, 期 6, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.02935-20
关键词
infants; parechovirus; enterovirus; epidemiology; central nervous system infections; children
类别
A study on pediatric central nervous system infections in the United States found that picornaviruses, such as EV and PeV-A, were the most common causes, with PeV-A3 being the dominant type. The detection of multiple EV and two PeV-A types in children's cerebrospinal fluid suggests routine testing and reporting of PeV-A, especially in infants under 6 months old. This could help reduce hospital stays and antibiotic usage in young children with acute febrile illnesses.
Picornaviruses, including Enterovirus species A to D (EV) and Parechovirus species A (PeV-A), are the leading reported causes of pediatric central nervous system infections in the United States. We investigated the molecular epidemiology of EV and PeV-A over 10 years in cerebrospinal fluid (CSF) collected from children seen at Children's Mercy-Kansas City (CMKC) from 2007 through 2016. The overall prevalence for EV was 16% (862/5,362) and 7% (271/4,016) for PeV. Among all picornavirus CSF detections, EV was 76%, and PeV-A was 24%. Multiple EV types cocirculated each year, with a total of 31 EV types detected in the 10-year period; the majority belonged to EV-B species (96%). Two PeV-A types were detected; PeV-A3 was the dominant PeV-A type (95%). The top five picornaviruses (PeV-A3, 26%; E30, 11%; E6, 10%; E18, 9%; E9, 7%) in the CSF of infants accounted for two-thirds of all detections, and PeV-A3 was the leading picornavirus detected. Routine testing and reporting of PeV-A in addition to EV, especially in children under 6 months old with acute febrile illnesses, could reduce hospital stays and antibiotic usage.
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