Solubility determination, model evaluation, Hansen solubility parameter and thermodynamic properties of benorilate in six pure solvents and two binary solvent mixtures

The equilibrium solubility and thermodynamic properties of benorilate in six pure solvents (methyl acetate, n-propyl acetate, n-butyl acetate, n-pentyl acetate, DMAC and DMSO) and two binary solvents (DMAC + n-pentyl acetate, DMSO + n-pentyl acetate) were reported. Solubility determinations were performed through the laser monitoring method at T = (278.15-323.15) K and p = 0.1 MPa, except DMSO at (293.15-323.15) K. The measurement results illustrated that the solubility of benorilate in all the six mono-solvents and two binary solvents shows a positive relation with temperature variation. And with the mass fraction of positive solvents (DMAC, DMSO) in the binary mixed solvents increasing, the solubility of benorilate also rises. And then, the Hansen solubility parameter (HSP) of benorilate as well as solvents selected were summarized to analyse the probabilities of miscibility between solute and solvents. The results indicate that the HSP could explain the solubility trend well, and the miscibility of benorilate with selected solvents is caused by a combination of factors. In addition, all recorded solubility of benorilate in pure solvents were regressed by lambda h, modified Apleblat, Two-Suffix Margules, NRTL and UNIQUAC models, while solubility of benorilate in two binary solvents were regressed by lambda h, modified Apleblat, Three-Suffix Margules, NRTL and UNIQUAC models. By calculating the deviation between the experimental data and the regression data, it shows that the modified Apelblat model and lambda h model can provide more accurate correlation results for the solubility of benorilate in all the solvents studied. Furthermore, the apparent thermodynamic properties of benorilate in all solvents were calculated and investigated by the Van't Hoff equation. The results demonstrate that the dissolution process of benorilate is an endothermic, non-spontaneous process driven by entropy. (C) 2020 Elsevier Ltd.

Automated summary

This study investigated the equilibrium solubility and thermodynamic properties of benorilate in various solvents, showing a positive correlation between solubility and temperature, as well as an increase in solubility with the mass fraction of positive solvents in binary mixed solvents. The Hansen solubility parameter was used to analyze the miscibility between solute and solvents, with results indicating a combination of factors affecting the solubility trend. Furthermore, regression models were used to predict solubility, with the modified Apelblat and lambda h models providing more accurate correlation results for benorilate solubility. Additionally, the dissolution process was found to be endothermic and non-spontaneous driven by entropy.