4.5 Article

The novel membrane protein Hoka regulates septate junction organization and stem cell homeostasis in the Drosophila gut

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Review Physiology

The Drosophila septate junctions beyond barrier function: Review of the literature, prediction of human orthologs of the SJ-related proteins and identification of protein domain families

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Summary: This study provides a comprehensive overview of the functions of Drosophila melanogaster SJ-related proteins, their human orthologs, and protein domain families, highlighting their roles in morphogenetic events and cellular signaling. The investigation also reveals the presence of conserved domains in SJ-related proteins essential for cell-cell interactions, cell polarity, signaling, and immunity, and identifies novel human genes as putative functional homologs of fruit fly SJ genes. Further research is needed to explore the domains present in proteins encoded by eight SJ-associated genes.

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