期刊
JOURNAL OF CELL SCIENCE
卷 134, 期 5, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.252023
关键词
Microbes; Metabolism; Mitochondria; Nutrients; Metabolites; Cellular defense; Immunity; Host-pathogen interaction
类别
资金
- Max Planck Society
- European Research Council [ERCStG-852457]
- Deutsche Forschungsgemeinschaft [RTG2550, CRC1218]
The study discusses the resistance of host cell metabolism against pathogens and highlights how rewiring metabolic processes can enhance cellular defenses and hinder microbial growth.
The study of metabolic changes associated with host-pathogen interactions have largely focused on the strategies that microbes use to subvert host metabolism to support their own proliferation. However, recent reports demonstrate that changes in host cell metabolism can also be detrimental to pathogens and restrict their growth. In this Review, I present a framework to consider how the host cell exploits the multifaceted roles of metabolites to defend against microbes. I also highlight how the rewiring of metabolic processes can strengthen cellular barriers to microbial invasion, regulate microbial virulence programs and factors, limit microbial access to nutrient sources and generate toxic environments for microbes. Collectively, the studies described here support a critical role for the rewiring of cellular metabolism in the defense against microbes. Further study of host-pathogen interactions from this framework has the potential to reveal novel aspects of host defense and metabolic control, and may inform how human metabolism impacts the progression of infectious disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据