期刊
JOURNAL OF CATALYSIS
卷 396, 期 -, 页码 291-296出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcat.2021.02.032
关键词
Dihydrobenzofuran; Diastereoselective; O-ylide; Palladium; Michael addition
资金
- DST-SERB, New Delhi, India [EMR/2016/003677]
- CSIR
- UGC
An efficient palladium-catalyzed diastereoselective synthesis of 2,2,3-trisubstituted dihydrobenzofurans has been achieved in good yield as a single diastereomer. The transformation involves in-situ generation of oxonium ylide from 2-hydroxyphenyl substituted enone and diazo compound followed by intramolecular trapping via Michael addition, leading to potent dibenzofuran derivatives in good yield.
An efficient palladium catalyzed diastereoselective synthesis of 2,2,3-trisubstituted dihydrobenzofurans has been accomplished in good yield as a single diastereomer. The transformation involves in-situ generation of oxonium ylide from 2-hydroxyphenyl substituted enone and diazo compound followed by intramolecular trapping via Michael addition. Successful integration of the developed method with intramolecular aldol condensation afforded potent dibenzofuran derivatives in good yield. (c) 2021 Elsevier Inc. All rights reserved.
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