期刊
JOURNAL OF BIOMECHANICS
卷 117, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2021.110263
关键词
Bone tissue engineering; Scaffolds; Permeability; Triply periodic minimal surfaces; Computational fluid dynamics
资金
- Portuguese Science and Technology Foundation, through IDMEC, under LAETA [UIDB/50022/2020, PTDC/BBB-BMC/5655/2014]
- Fundação para a Ciência e a Tecnologia [PTDC/BBB-BMC/5655/2014] Funding Source: FCT
Experimental and computational analysis were used to assess the permeability and fluid streamlines within different scaffold geometries, with Gyroid structures being most suitable for bone tissue engineering applications, while Schwarz P structures were found to provide a poor environment for cell seeding and proliferation.
Bone Tissue Engineering has been focusing on improving the current methods for bone repair, being the use of scaffolds presented as an upgrade to traditional surgery techniques. Scaffolds are artificially porous matrices, meant to promote cell seeding and proliferation, being these properties influenced by the permeability of the structure. This work employed experimental pressure drop tests and Computational Fluid Dynamics models to assess permeability (and fluid streamlines) within different triply periodic minimal surfaces scaffold geometries (Schwarz D, Gyroid and Schwarz P). The pressure outputs from the computational analysis presented a good correlation with the experimental results, with R2 equal to 0.903; they have also shown that a lower porosity may not mean a lower permeability if the geometry is altered, such as the difference between 60% porous Gyroid scaffolds (8.1*10-9 mm2) and 70% porous Schwarz D scaffolds (7.1*10-9 mm2). Fluid streamlines revealed how the Gyroid geometries are the most appropriate design for most bone tissue engineering applications, due to their consistent fluid permeation, followed by Schwarz D. The Schwarz P geometries have shown flat streamlines and significant variation of the permeability with the porosity (an increase of 10% in their porosity lead to an increase in the permeability from 5.1*10-9 mm2 to 11.7*10-9 mm2), which would imply a poor environment for cell seeding and proliferation. (c) 2021 Elsevier Ltd. All rights reserved.
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