4.4 Article

Gelatin/poly(vinyl alcohol) based hydrogel film - A potential biomaterial for wound dressing: Experimental design and optimization followed by rotatable central composite design

期刊

JOURNAL OF BIOMATERIALS APPLICATIONS
卷 36, 期 4, 页码 682-700

出版社

SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328221992260

关键词

Hydrogel films; physical crosslinking; UV light; wound dressings; experimental design

资金

  1. Brazilian National Council for Scientific and Technological Development (CNPq)
  2. Coordination for the Improvement of Higher-Level Personnel (CAPES)

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Hydrogel films based on gelatin and PVA were developed and optimized using a central composite design method, showing characteristics suitable for biomedical applications such as wound dressings. The optimized film had good mechanical resistance, elasticity, and permeability to oxygen, making it a promising candidate for use in biomedical settings.
The development of hydrogel films for biomedical applications is interesting due to their characteristics. Hydrogel films based on gelatin and poly(vinyl alcohol) (PVA) are developed and characterized using a rotatable central composite design. The optimized hydrogel film is obtained by the function desirability of the Statistica (R) software and is also characterized by swelling kinetics, oxygen permeability, adhesiveness, TGA, DSC, and XRD. The results of the experimental design show that gelatin and PVA concentrations have a significant influence on the response variables, and the exposure doses to UV light show no significant effect. The optimized hydrogel film is elastic, presents good mechanical resistance and swelling capacity in water and exudate solution, is permeable to oxygen, and is capable of adjusting itself and maintains contact close to the skin. In this way, considering all the properties evaluated, the optimized film has characteristics suitable for biomedical applications as wound dressings.

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