Antibiotic-loaded wound dressings obtained from the PBAT-gentamicin combination

The development of biodegradable curative systems containing antibacterial drug are fundamental for the promotion of therapeutic actions, reducing the infections caused by microorganisms and being able to substitute conventional dressings which are not biodegradable polymers in their composition. Meeting those needs, poly (butylene adipate-co-terephthalate) (PBAT) and PBAT/gentamicin (GT) fibers were electrospun using different concentrations of GT. The physical-chemical, morphological, thermal, antibacterial, and biological properties of the PBAT and PBAT/GT fibers were characterized. The presence of GT modified the mean diameter, roughness, and wettability of the prepared fibers. The degree of swelling was altered with the addition of GT. PBAT/GT fibers showed antibacterial activity against Escherichia coli strains reaching an inhibitory activity above 90% in the films with 2%, 5%, and 10% of GT. In addition, the fibers did not present cytotoxicity according to ISO 10993-5 standard. The obtained results reinforce that PBAT can be used as a curative system.

Automated summary

The presence of GT modified the physical and chemical properties of the fibers, showing antibacterial activity against Escherichia coli strains, and did not present cytotoxicity.