4.5 Article

Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction

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Summary: Liquid chromatography-mass spectrometry was used to analyze cerebrospinal fluid samples collected before, 24 hours after, and 6 weeks after surgery, revealing detectable levels of AA, DHA, and EPA derived lipids in human CSF, with significant postoperative changes observed in the AA metabolite pathway in centrifuged CSF pellets and supernatants.

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