期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 80, 期 2, 页码 665-672出版社
IOS PRESS
DOI: 10.3233/JAD-201442
关键词
Alzheimer's disease; causal relations; social interaction; social isolation; Mendelian randomization
资金
- Medical Research Council [MC UU 12015/2]
- Netherlands Organization for Scientific Research [NWO VICI 453-14-005]
- National Natural Science Foundation of China [91849126]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]
- Zhangjiang Lab of Ministry of Education, Fudan University
- Tianqiao and Chrissy Chen Institute of Ministry of Education, Fudan University
- State Key Laboratory of Neurobiology and Frontiers Center for Brain Science of Ministry of Education, Fudan University
This study using Mendelian randomization method suggests a causal relationship between regular attendance at a gym or sports club and reduced risk of Alzheimer's disease, while Alzheimer's disease may reduce attendance at religious groups. Further research is needed to elucidate potential mechanisms.
Background: Social isolation and social interaction have been suggested to be associated with Alzheimer's disease. However, the causality cannot be unambiguously assessed as traditional epidemiological methods are easily subject to unmeasured confounders and potential bias. Objective: To examine bidirectional relationships between social isolation, social interaction, and Alzheimer's disease using Mendelian randomization method for assessing potential causal inference. Methods: This bidirectional two-sample Mendelian randomization study used independent genetic variants associated with social isolation and social interaction (n = 302,567-487,647), and Alzheimer's disease (n = 455,258). MR analyses were performed using the inverse-variance-weighted (IVW) as the main MR analytical method to estimate the causal effect. For sensitivity analyses, we applied weighted median, MR Egger to further assess the credibility of the causal effect. Results: Of the five types of social engagement examined in our study, only one showed evidence of an association with the risk of Alzheimer's disease. Attendance at a gym or sports club (IVW OR per SD change: 0.670; 95% CI: 0.463-0.970; p = 0.034) was inversely associated with the risk of Alzheimer's disease. We also found that AD may reduce the attendance at religious group (IVW OR per SD change: 1.017; 95% CI: 1.005-1.030; p = 0.004). Conclusion: This study suggests that regular attendance at a gym or sports club is causally associated with reduced risk of Alzheimer's disease. Further studies are warranted to elucidate potential mechanisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据