期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 69, 期 5, 页码 1693-1704出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c07456
关键词
botanical estrogens; endocrine-disrupting chemical (EDC); endometrium; myometrium; luminal epithelium; hyperplasia
资金
- NIH [R03ES023972]
- Toxicology Scholar Award
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico of Brazil (CNPq)
The study found that chronic intake of genistein may have an impact on the uterus of mice, but does not cause persistent harm to the organ.
Genistein is naturally occurring in plants and binds to estrogen receptors. Humans are mainly exposed through diet, but the use of supplements is increasing as genistein is claimed to promote health and alleviate menopausal symptoms. We analyzed diverse uterine features in adult mice chronically fed genistein for different times. The luminal epithelium height was increased in females treated with 500 and 1000 ppm at PND 95, and the width of the outer myometrium was increased in females treated with 1000 ppm at PND 65 compared to that in controls. An increase in proliferation was noted in the inner myometrium layer of animals exposed to 300 ppm genistein at PND 185 compared to that in controls. Luminal hyperplasia was greater in the 1000 ppm group at PND 65, 95, and 185, although not statistically different from control. These results indicate that genistein may exert estrogenic activity in the uterus, without persistent harm to the organ.
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