期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 69, 期 11, 页码 3326-3339出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c07407
关键词
lychee; phenolic; dextran sulfate sodium; gut microbiota; Bacteroides uniformis
资金
- National Natural Science Foundation of China [31601469]
- Scientific Research Program of Guangzhou [201804020064]
The study found that supplementation with lychee pulp phenolics (LPP) could alleviate DSS-induced gut barrier damage, activate the microbiota-SCFA-FFAR signaling cascade, and suppress the TLR4/NLRP3-NF-κB pathway, showing promise in protecting the intestinal tract.
The preventive effect of lychee pulp phenolics (LPP) on dextran sulfate sodium (DSS)-induced colitis of mice and its underlying mechanisms were investigated in this research. LPP supplementation mitigated DSS-induced breakage of the gut barrier as evidenced by the increased tight junction proteins and the enhanced integrity of epithelial cells. Both LPP and 5-ASA treatments could downregulate the expressions of toll-like receptor 4 (TLR-4), NOD protein-like receptor 3 (NLRP3), and proinflammatory cytokines to normal levels. Notably, treatment with LPP at a dosage of 500 mg/kg/day effectively upregulated FFAR2 and FFAR3 expression and contents of short-chain fatty acids (SCFAs), suggesting the activation of the SCFA-FFAR (free fatty acid receptor) pathway. Consistently, the abundances of probiotic taxa and microbiota (Akkermansia, Lactobacillus, Coprococcus, and Bacteroides uniformis) associated with SCFA synthesis were elevated, whereas harmful bacteria (Enterococcus and Aggregatibacter) were suppressed. These data indicate that LPP ameliorates gut barrier damage, activates the microbiota-SCFA-FFAR signaling cascade, and suppresses the TLR4/NLRP3-NF-kappa B pathway, and therefore, LPP supplementation could be a promising way to protect the intestinal tract.
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