期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 69, 期 7, 页码 2157-2167出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c07085
关键词
nonsteroidal anti-inflammatory drugs; intestinal permeability; onion aqueous extract; benzofuranone; antioxidants; phenolic compounds; nuclear factor kappa B
资金
- CONICYT [FONDECYT-1190053, 21180410]
The study investigated the protective effects of BZF and BZF-rich OAE against oxidative stress and increased permeability induced by NSAIDs, finding that the prevention of NSAIDs-induced oxidative stress and NF-kappa B activation plays no fundamental role in the IP-protecting effect of OAE, except for with indomethacin.
The potential of 2-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone (BZF), a quercetin oxidation metabolite, and that of a BZF-rich onion peel aqueous extract (OAE) to protect Caco-2 monolayers against the oxidative stress (OS) and an increased permeability (IP) induced by five nonsteroidal anti-inflammatory drugs (NSAIDs) (indomethacin, didofenac, piroxicam, ibuprofen, and metamizole) were investigated. Under identical OS conditions, the NSAIDs substantially differed in their ability to induce an IP and/or NF-kappa B activation. The OAE (100 nM BZF) protected in identical magnitude (84-86%) against OS but in a highly dissimilar manner against the IP (18-73%). While all NSAIDs activated NF-kappa B, the OAE prevented only that induced by indomethacin. Results reveal that the IP has no direct relationship with the OS and that with the exception of indomethacin, the prevention of NSAIDs-induced OS and/or NF-kappa B activation plays no fundamental role in the IP-protecting effect of OAE. These results warrant the in vivo evaluation of OAE against indomethacin-induced loss of intestinal barrier function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据